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Gene FGFR2
Variant R255Q
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 R255Q lies within the extracellular domain of the Fgfr2 protein (UniProt.org). R255Q results in decreased activation of Fgfr2 downstream signaling upon Fgf2 stimulation in culture (PMID: 27323706), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 R255Q

FGFR2 mutant FGFR2 inact mut FGFR2 R255Q

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Transcript NM_000141.5
gDNA chr10:g.121520154C>T
cDNA c.764G>A
Protein p.R255Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.3 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_022970 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_000141 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520154C>T c.764G>A p.R255Q RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References