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Gene DNMT3A
Variant R882S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions DNMT3A R882S lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). R882S results in a loss of Dnmt3a protein function, as demonstrated by cytokine-independent growth and hypomethylation in cultured cells (PMID: 31164355).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A inact mut DNMT3A R882S

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Transcript NM_022552.5
gDNA chr2:g.25234374G>T
cDNA c.2644C>A
Protein p.R882S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017003526.1 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
XM_005264175 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
XM_017003526 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
NM_175629 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38
NM_022552 chr2:g.25234374G>T c.2644C>A p.R882S RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References