NRAS G12D
Gene Variant Detail

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Gene NRAS
Variant G12D
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12D results in decreased intrinsic GTPase activity, reduced sensitivity to GTPase-activating proteins (PMID: 25252692), leading to accumulation of GTP-bound Nras, activation of downstream signaling, and transformation of cultured cells (PMID: 19075190, PMID: 35211470), but does not promote tumorigenesis in a mouse model (PMID: 25252692), and therefore, is predicted to lead to a loss of Nras prein function and activation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12D

NRAS mutant NRAS exon2 NRAS G12X NRAS G12D

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Transcript NM_002524.5
gDNA chr1:g.114716126C>T
cDNA c.35G>A
Protein p.G12D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716126C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_002524 chr1:g.114716126C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716126C>T c.35G>A p.G12D RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
NRAS G12D loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF D594G NRAS G12D
DNMT3A R882H NRAS G12D
FLT3 exon 14 ins NRAS G12D
FLT3 exon 14 ins FLT3 D835X NRAS G12D NRAS G12S
CBL Q367_E373delinsRLK FLT3 exon 14 ins FLT3 D835X NRAS G12D
NRAS G12D NRAS L95H