ROS1 F2004V
Gene Variant Detail

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Gene ROS1
Variant F2004V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 F2004V lies within the protein kinase domain of the Ros1 protein (UniProt.org). F2004V has been demonstrated to confer resistance to ROS1 tyrosine kinase inhibitors in the context of a ROS1 fusion (PMID: 28717217, PMID: 32914039), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 F2004V

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Transcript NM_002944.3
gDNA chr6:g.117317268A>C
cDNA c.6010T>G
Protein p.F2004V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536049.2 chr6:g.117318213A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
NM_002944 chr6:g.117317268A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
XM_011536054.3 chr6:g.117318213A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
XM_011536049 chr6:g.117318213A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117317268A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
XM_011536054.2 chr6:g.117318213A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
XM_011536049.3 chr6:g.117318213A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117317268A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38
XM_011536054 chr6:g.117318213A>C c.6010T>G p.F2004V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References