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Gene FGFR2
Variant S780L
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 S780L lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). S780L results in sustained Fgfr2 phosphorylation and faster cell migration in response to Fgf1 in cell culture (PMID: 31146385), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 S780L

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Transcript NM_000141.5
gDNA chr10:g.121479984G>A
cDNA c.2339C>T
Protein p.S780L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121479984G>A c.2339C>T p.S780L RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121479978_121479979delAGinsCT c.2338_2339delAGinsCT p.S780L RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121479978_121479979delAGinsCT c.2338_2339delAGinsCT p.S780L RefSeq GRCh38/hg38
NM_000141 chr10:g.121479984G>A c.2339C>T p.S780L RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121479984G>A c.2339C>T p.S780L RefSeq GRCh38/hg38
NM_001320658 chr10:g.121479978_121479979delCTinsAG c.2338_2339delAGinsCT p.S780L RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries