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Gene KIT
Variant P874L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KIT P874L lies within the protein kinase domain of the Kit protein (UniProt.org). P874L corresponds to P875L in an alternate isoform, which results in similar levels of autophosphorylation but decreased transformation relative to wild-type in culture (PMID: 30926633), and therefore, its effect on Kit protein function is unknown.
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT P874L

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Transcript NM_000222.3
gDNA chr4:g.54736745C>T
cDNA c.2621C>T
Protein p.P874L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222.3 chr4:g.54736745C>T c.2621C>T p.P874L RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54736745C>T c.2621C>T p.P874L RefSeq GRCh38/hg38
XM_005265741 chr4:g.54736745C>T c.2621C>T p.P874L RefSeq GRCh38/hg38
XM_005265741.1 chr4:g.54736745C>T c.2621C>T p.P874L RefSeq GRCh38/hg38
NM_000222 chr4:g.54736745C>T c.2621C>T p.P874L RefSeq GRCh38/hg38
NM_001385290.1 chr4:g.54736745C>T c.2621C>T p.P874L RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References