NRAS G60R - Gene Variant Detail

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Gene NRAS
Variant G60R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G60R lies within a GTP binding region of the Nras protein (UniProt.org). G60R has not been characterized, but can be predicted to lead to a loss of Nras protein function and activation of downstream signaling based on the effects of KRAS G60R (PMID: 20949621).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G60R

NRAS mutant NRAS exon3 NRAS G60R

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Transcript NM_002524.5
gDNA chr1:g.114713912C>T
cDNA c.178G>A
Protein p.G60R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114713912C>T c.178G>A p.G60R RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713912C>T c.178G>A p.G60R RefSeq GRCh38/hg38
NM_002524 chr1:g.114713912C>T c.178G>A p.G60R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References