NRAS G12S
Gene Variant Detail

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Gene NRAS
Variant G12S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS G12S is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12S results in increased Erk phosphorylation and cell proliferation (PMID: 17823240), increased Stat5 phosphorylation in culture (PMID: 35211470), is transforming in one study (PMID: 17823240), but is not transforming in another study (PMID: 35211470), and therefore, its effect on Nras protein function is unknown.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon2 NRAS G12X NRAS G12S

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Transcript NM_002524.5
gDNA chr1:g.114716127C>T
cDNA c.34G>A
Protein p.G12S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716127C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_002524 chr1:g.114716127C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716127C>T c.34G>A p.G12S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 D835X NRAS G12D NRAS G12S acute myeloid leukemia predicted - resistant Gilteritinib Case Reports/Case Series Actionable In a clinical study, a patient with acute myeloid leukemia harboring FLT3-ITD and a D835 mutation progressed on Xospata (gilteritinib) treatment and was found to have acquired NRAS G12S and G12D (PMID: 31088841). 31088841