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Gene PIK3CA
Variant P539R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA P539R lies within the PIK helical domain of the Pik3ca protein (UniProt.org). P539R increases the stability of the Pik3ca protein, confers a gain of function, as indicated by constitutive phosphorylation of downstream targets Akt and S6, and is transforming in cell culture (PMID: 18951408, PMID: 17376864, PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA P539R

PIK3CA mutant PIK3CA exon10 PIK3CA P539R

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Transcript NM_006218.4
gDNA chr3:g.179218286C>G
cDNA c.1616C>G
Protein p.P539R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
NM_006218 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA P539R gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
PIK3CA P539R PIK3CA H1047R
FGFR2 N550K PIK3CA I20M PIK3CA P539R PTEN R130Q PTEN T321fs
PIK3CA P539R PIK3CA H1047R PTEN del