NRAS S89D
Gene Variant Detail

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Gene NRAS
Variant S89D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS S89D does not lie within any known functional domains of the Nras protein (UniProt.org). S89D results in cell proliferation, colony formation and activation of Nras signaling similar to wild-type Nras in culture, but results in increased NRAS signaling and colony formation when combined with NRAS Q61R (PMID: 30712867), and therefore, its effect on Nras protein function is unknown.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS S89D

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Transcript NM_002524.5
gDNA chr1:g.114713823_114713825delTCAinsGAC
cDNA c.265_267delTCAinsGAC
Protein p.S89D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713823_114713825delTCAinsGAC c.265_267delTCAinsGAC p.S89D RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713823_114713825delTCAinsGAC c.265_267delTCAinsGAC p.S89D RefSeq GRCh38/hg38
NM_002524 chr1:g.114713823_114713825delTGAinsGTC c.265_267delTCAinsGAC p.S89D RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References