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Gene APC
Variant N1142Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC N1142Y lies within the beta-catenin binding domain of the Apc protein (PMID: 14672538). N1142Y has been identified in sequencing studies (PMID: 24983367), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC N1142Y

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Transcript NM_000038.6
gDNA chr5:g.112839018A>T
cDNA c.3424A>T
Protein p.N1142Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354896.1 chr5:g.112838964A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_000038 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001407447.1 chr5:g.112838964A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.112839093A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001407448.1 chr5:g.112838964A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839018A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001407449.1 chr5:g.112838964A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001354896.2 chr5:g.112838964A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.112839093A>T c.3424A>T p.N1142Y RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References