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Gene APC
Variant P1453S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC P1453S lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). P1453S has been identified in sequencing studies (PMID: 16906516), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC P1453S

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Transcript NM_000038.6
gDNA chr5:g.112839951C>T
cDNA c.4357C>T
Protein p.P1453S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.6 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_000038 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001354897.2 chr5:g.112839921C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001354905.1 chr5:g.112840431C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001354897.1 chr5:g.112839921C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839951C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38
NM_001354905.2 chr5:g.112840431C>T c.4357C>T p.P1453S RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC P1453S unknown