RAD51D E233G
Gene Variant Detail

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Gene RAD51D
Variant E233G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51D E233G lies within the ATPase domain of the Rad51d protein (PMID: 28646019). E233G results in homologous recombination-mediated DNA repair activity similar to wild-type Rad51d in cell culture (PMID: 28646019), but in another study, results in increased cell proliferation and telomere maintenance dysfunction in culture (PMID: 19033885), and has been demonstrated to confer resistance to cisplatin in cultured cells with decreased Tp53 expression (PMID: 19347880), and therefore, its effect on Rad51d protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51D mutant RAD51D E233G

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Transcript NM_002878.4
gDNA chr17:g.35103294T>C
cDNA c.698A>G
Protein p.E233G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002878 chr17:g.35103294T>C c.698A>G p.E233G RefSeq GRCh38/hg38
NM_002878.3 chr17:g.35103294T>C c.698A>G p.E233G RefSeq GRCh38/hg38
NM_002878.4 chr17:g.35103294T>C c.698A>G p.E233G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References