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Gene PIK3CA
Variant E542X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E542X indicates any Pik3ca missense mutation that results in the replacement of the glutamic acid (E) at amino acid 542 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA E542X

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Transcript NM_006218.4
gDNA chr3:g.179218294_179218296
cDNA c.1624_1626
Protein p.E542
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179218294_179218296 c.1624_1626 p.E542 RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218294_179218296 c.1624_1626 p.E542 RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218294_179218296 c.1624_1626 p.E542 RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218294_179218296 c.1624_1626 p.E542 RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218294_179218296 c.1624_1626 p.E542 RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05768139 Phase Ib/II Fulvestrant + STX-478 STX-478 First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors Recruiting USA | ITA | FRA | ESP 0
NCT03842228 Phase I Copanlisib + Durvalumab + Olaparib Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations Active, not recruiting USA 0