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Gene PTEN
Variant T401*
Impact List nonsense
Protein Effect no effect - predicted
Gene Variant Descriptions PTEN T401* results in a premature truncation of the Pten protein at amino acid 401 of 403 (UniProt.org). T401* demonstrates protein stability and the ability to inhibit Akt phosphorylation and cell transformation to similar levels as wild-type Pten in culture (PMID: 10468583), and therefore, is predicted to have no effect on Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN T401*

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Transcript NM_000314.8
gDNA chr10:g.87965461_87965462delACinsTA
cDNA c.1201_1202delACinsTA
Protein p.T401*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314 chr10:g.87965461_87965462delACinsTA c.1201_1202delACinsTA p.T401* RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87965461_87965462delACinsTA c.1201_1202delACinsTA p.T401* RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87965461_87965462delACinsTA c.1201_1202delACinsTA p.T401* RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References