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Gene PTEN
Variant Y379*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions PTEN Y379* results in a premature truncation of the Pten protein at amino acid 379 of 403 (UniProt.org). Y379* results in decreased Pten protein expression in cultured cells (PMID: 10468583), but has not been fully biochemically characterized and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN Y379*

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Transcript NM_000314.8
gDNA chr10:g.87965397T>A
cDNA c.1137T>A
Protein p.Y379*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87965397T>A c.1137T>A p.Y379* RefSeq GRCh38/hg38
NM_000314 chr10:g.87965397T>A c.1137T>A p.Y379* RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87965397T>A c.1137T>A p.Y379* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References