PTEN V351*
Gene Variant Detail

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Gene PTEN
Variant V351*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions PTEN V351* results in a premature truncation of the Pten protein at amino acid 351 of 403 (UniProt.org). V351* demonstrates phosphatase activity and inhibition of Akt phosphorylation similar to wild-type, but results in decreased Pten protein stability and reduced ability to inhibit transformation in culture (PMID: 10468583), and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN V351*

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Transcript NM_000314.8
gDNA chr10:g.87965311_87965312delGTinsTA
cDNA c.1051_1052delGTinsTA
Protein p.V351*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314 chr10:g.87965311_87965312delGTinsTA c.1051_1052delGTinsTA p.V351* RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87965311_87965312delGTinsTA c.1051_1052delGTinsTA p.V351* RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87965311_87965312delGTinsTA c.1051_1052delGTinsTA p.V351* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References