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Gene FGFR1
Variant A645V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions FGFR1 A645V lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). A645V results in a loss of function of the Fgfr1 protein as demonstrated by decreased Erk activation and c-Fos expression and elevated autophagy in cell culture (PMID: 30787447).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 inact mut FGFR1 A645V

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Transcript NM_023110.3
gDNA chr8:g.38414822G>A
cDNA c.1934C>T
Protein p.A645V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013221.2 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_006716303 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_017013221 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
XM_006716304 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38
NM_023110 chr8:g.38414822G>A c.1934C>T p.A645V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References