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Gene PIK3CA
Variant T1052K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA T1052K does not lie within any known functional domains of the Pik3ca protein (UniProt.org). T1052K has been identified in the scientific literature (PMID: 31410178, PMID: 21725289, PMID: 27672108), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA T1052K

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Transcript NM_006218.4
gDNA chr3:g.179234312C>A
cDNA c.3155C>A
Protein p.T1052K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
NM_006218 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA R88L PIK3CA E453del PIK3CA T1052K PTEN loss PTEN mut
PIK3CA T1052K unknown