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Gene APC
Variant R876*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC R876* results in a premature truncation of the Apc protein at amino acid 876 of 2843 (UniProt.org). R876* has not been characterized, however, due to the effects of other truncation mutations downstream of R876 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC R876*

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Transcript NM_000038.6
gDNA chr5:g.112838220C>T
cDNA c.2626C>T
Protein p.R876*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.1 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_001354899.2 chr5:g.112838304A>T c.2626A>T p.R876* RefSeq GRCh38/hg38
NM_000038 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_001354899.1 chr5:g.112838304A>T c.2626A>T p.R876* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838220C>T c.2626C>T p.R876* RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC R876* colorectal cancer sensitive G007-LK Preclinical - Patient cell culture Actionable In a preclinical study, G007-LK inhibited viability of a patient-derived colorectal cancer cell line harboring APC R876* in culture (PMID: 37968472). 37968472
APC R876* colorectal cancer sensitive Buparlisib + G007-LK Preclinical - Cell culture Actionable In a preclinical study, the combination of G007-LK and Buparlisib (BKM120) inhibited viability of a colorectal cancer patient-derived cell line harboring APC R876* in culture (PMID: 37968472). 37968472