PIK3CA R88Q
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene PIK3CA
Variant R88Q
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA R88Q lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R88Q does not result in activation of Akt in culture in one study (PMID: 34779417) but confers a gain of function to the Pik3ca protein as indicated by increased phosphorylation of downstream targets, including Akt and S6 (PMID: 18829572), increased cell proliferation and migration (PMID: 34779417), and transformation in culture (PMID: 29533785, PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA R88Q

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_006218.4
gDNA chr3:g.179199088G>A
cDNA c.263G>A
Protein p.R88Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
NM_006218 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05455619 Phase Ib/II Capivasertib + Fulvestrant + SDX-7320 Alpelisib + Fulvestrant + SDX-7320 Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/ Her2- Breast Cancer (Amelia-1) Recruiting USA 0