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Gene PIK3CA
Variant R88Q
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA R88Q lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R88Q confers a gain of function to the Pik3ca protein as indicated by increased phosphorylation of downstream targets Akt and S6, increased cell proliferation and migration, and is transforming in culture (PMID: 18829572, PMID: 29533785, PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA R88Q

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Transcript NM_006218.4
gDNA chr3:g.179199088G>A
cDNA c.263G>A
Protein p.R88Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
NM_006218 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199088G>A c.263G>A p.R88Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA R88Q gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
PIK3CA R88Q PTEN mut
HRAS mut PIK3CA R88Q