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| Gene | KDR |
| Variant | T761M |
| Impact List | missense |
| Protein Effect | unknown |
| Gene Variant Descriptions | KDR (VEGFR2) T761M lies within the extracellular domain of the Kdr (Vegfr2) protein (UniProt.org). T761M has been identified in sequencing studies (PMID: 26644315, PMID: 27683039, PMID: 30239046), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Jun 2026). |
| Associated Drug Resistance | |
| Category Variants Paths |
KDR mutant KDR T761M |
| Transcript | NM_002253.4 |
| gDNA | chr4:g.55098788G>A |
| cDNA | c.2282C>T |
| Protein | p.T761M |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_002253 | chr4:g.55098788G>A | c.2282C>T | p.T761M | RefSeq | GRCh38/hg38 |
| NM_002253.4 | chr4:g.55098788G>A | c.2282C>T | p.T761M | RefSeq | GRCh38/hg38 |
| NM_002253.3 | chr4:g.55098788G>A | c.2282C>T | p.T761M | RefSeq | GRCh38/hg38 |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|