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Gene | TP53 |
Variant | G279_R282del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 G279_R282del results in the deletion of four amino acids in the DNA-binding domain of the Tp53 protein from amino acids 279 to 282 (UniProt.org). G279_R282del has been identified in the scientific literature (PMID: 31837433), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Nov 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon8 TP53 G279_R282del |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673774_7673785del12 |
cDNA | c.835_846del12 |
Protein | p.G279_R282delGRDR |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001276695.3 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_001407267.1 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001126118.2 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001407265.1 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001407269.1 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001276760.3 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001407263.1 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001276696.3 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_001407271.1 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001276761.3 | chr17:g.7673565_7673576del12 | c.838_849del12 | p.K280_P283delKKKP | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282del | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7673774_7673785del12 | c.835_846del12 | p.G279_R282delGRDR | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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