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Gene TET2
Variant R1452*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 R1452* results in a premature truncation of the Tet2 protein at amino acid 1452 of 2002 (UniProt.org). R1452* has not been characterized however, due to the effects of other truncation mutations downstream of R1452 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 R1452*

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Transcript NM_001127208.3
gDNA chr4:g.105272735C>T
cDNA c.4354C>T
Protein p.R1452*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005263082.3 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
XM_005263082 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
NM_001127208 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105272735C>T c.4354C>T p.R1452* RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References