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Gene JAK2
Variant Y1045W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions JAK2 Y1045W lies within protein kinase domain 2 of the Jak2 protein (UniProt.org). Y1045W has been demonstrated to confer Jak2 inhibitor resistance in combination with V617F and Y931C in culture (PMID: 26419724), but has not been biochemically characterized and therefore, its effect on Jak2 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

JAK2 mutant JAK2 Y1045W

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Transcript NM_004972.4
gDNA chr9:g.5123078_5123079delATinsGG
cDNA c.3134_3135delATinsGG
Protein p.Y1045W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001322195 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_004972.3 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_004972.4 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322194.2 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322194 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322195.2 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322194.1 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_004972 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322196 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322196.1 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322195.1 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38
NM_001322196.2 chr9:g.5123078_5123079delATinsGG c.3134_3135delATinsGG p.Y1045W RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries