B2M T93Hfs*2
Gene Variant Detail

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Gene B2M
Variant T93Hfs*2
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions B2M T93Hfs*2 indicates a shift in the reading frame starting at amino acid 93 and terminating 2 residues downstream causing a premature truncation of the 119 amino acid B2m protein (UniProt.org). T93Hfs*2 has been identified in sequencing studies (PMID: 31008436, PMID: 36724040), but has not been biochemically characterized and therefore, its effect on B2m protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

B2M mutant B2M T93fs B2M T93Hfs*2

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Transcript NM_004048.4
gDNA chr15:g.44715631dupC
cDNA c.276dupC
Protein p.T93Hfs*2
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004048 chr15:g.44715631dupC c.276dupC p.T93Hfs*2 RefSeq GRCh38/hg38
NM_004048.2 chr15:g.44715631dupC c.276dupC p.T93Hfs*2 RefSeq GRCh38/hg38
NM_004048.4 chr15:g.44715631dupC c.276dupC p.T93Hfs*2 RefSeq GRCh38/hg38
XM_005254549.3 chr15:g.44715631dupC c.276dupC p.T93Hfs*2 RefSeq GRCh38/hg38
XM_005254549.4 chr15:g.44715631dupC c.276dupC p.T93Hfs*2 RefSeq GRCh38/hg38
XM_005254549 chr15:g.44715631dupC c.276dupC p.T93Hfs*2 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References