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Gene B2M
Variant L10P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions B2M L10P lies within the signal peptide region of the B2m protein (UniProt.org). L10P has been identified in the scientific literature (PMID: 31008436), but has not been biochemically characterized and therefore, its effect on B2m protein function is unknown (PubMed, Jan 2023).
Associated Drug Resistance
Category Variants Paths

B2M mutant B2M L10P

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Transcript NM_004048.4
gDNA chr15:g.44711575T>C
cDNA c.29T>C
Protein p.L10P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004048.2 chr15:g.44711575T>C c.29T>C p.L10P RefSeq GRCh38/hg38
NM_004048 chr15:g.44711575T>C c.29T>C p.L10P RefSeq GRCh38/hg38
XM_005254549 chr15:g.44711575T>C c.29T>C p.L10P RefSeq GRCh38/hg38
NM_004048.4 chr15:g.44711575T>C c.29T>C p.L10P RefSeq GRCh38/hg38
XM_005254549.3 chr15:g.44711575T>C c.29T>C p.L10P RefSeq GRCh38/hg38
XM_005254549.4 chr15:g.44711575T>C c.29T>C p.L10P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
B2M mutant colorectal cancer predicted - sensitive unspecified PD-1 antibody Clinical Study - Cohort Actionable In a clinical study, a cohort of colorectal cancer patients harboring B2M mutations demonstrated a clinical benefit of either a partial response or stable disease in 85% (11/13) when treated with a PD-1 or PD-L1 inhibitor (PMID: 31008436). 31008436
B2M mutant colorectal cancer predicted - sensitive unspecified PD-L1 antibody Clinical Study - Cohort Actionable In a clinical study, a cohort of colorectal cancer patients harboring B2M mutations demonstrated a clinical benefit of either a partial response or stable disease in 85% (11/13) when treated with a PD-1 or PD-L1 inhibitor (PMID: 31008436). 31008436