Gene Variant Detail

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Gene HRAS
Variant Y32S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS Y32S lies within the switch I region of the Hras protein (PMID: 11333268). Y32S results in a moderate increase of nucleotide exchange rate, but decreased binding to Sos and reduced sensitivity to Sos-mediated nucleotide exchange (PMID: 11333268), and therefore, its effect on Hras protein function is unknown.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS Y32S

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Transcript NM_005343.4
gDNA chr11:g.534228T>G
cDNA c.95A>C
Protein p.Y32S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_176795 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_005343 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38
NM_001130442 chr11:g.534228T>G c.95A>C p.Y32S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References