Gene Variant Detail

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Gene HRAS
Variant N116Q
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions HRAS N116Q lies within a nucleotide-binding region of the Hras protein (UniProt.org). N116I results in GTPase activity similar to wild-type Hras and is not transforming in cell culture (PMID: 3487832), and therefore, is predicted to have no effect on Hras protein function.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS N116Q

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Transcript NM_005343.4
gDNA chr11:g.533555_533557delAACinsCAA
cDNA c.346_348delAACinsCAA
Protein p.N116Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442 chr11:g.533555_533557delGTTinsTTG c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533555_533557delAACinsCAA c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_005343 chr11:g.533555_533557delGTTinsTTG c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533555_533557delAACinsCAA c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533555_533557delAACinsCAA c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533555_533557delAACinsCAA c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533555_533557delAACinsCAA c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_176795 chr11:g.533555_533557delGTTinsTTG c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533555_533557delAACinsCAA c.346_348delAACinsCAA p.N116Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS N116Q no effect - predicted