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FLT3 E598_Y599insFDFREYE - Gene Variant Detail

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Gene FLT3
Variant E598_Y599insFDFREYE
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 E598_Y599insFDFREYE results in the insertion of seven amino acids in the Flt3 protein between amino acids 598 and 599 (UniProt.org). E598_Y599insFDFREYE has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 E598_Y599insFDFREYE

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 E598_Y599insFDFREYE

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Transcript NM_004119.3
gDNA chr13:g.28034124_28034125insCTCATACTCCCTAAAGTCAAA
cDNA c.1795_1796insTTGACTTTAGGGAGTATGAGT
Protein p.E598_Y599insFDFREYE
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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