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| Gene | PIK3CA |
| Variant | wild-type |
| Impact List | none |
| Protein Effect | no effect |
| Gene Variant Descriptions | Wild-type PIK3CA indicates that no mutation has been detected within the PIK3CA gene. |
| Associated Drug Resistance | |
| Category Variants Paths |
PIK3CA wild-type |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03457896 | Phase II | Cetuximab + Neratinib Neratinib + Trastuzumab | Study of Neratinib +Trastuzumab or Neratinib + Cetuximab in Patients With KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer by HER2 Status | Unknown status | USA | 0 |
| NCT01960023 | Phase Ib/II | Cetuximab + Neratinib | Safety and Efficacy Study of Neratinib and Cetuximab to Treat Patients With Quadruple Wild-Type Metastatic Colorectal Cancer | Withdrawn | USA | 0 |