KIT D816G
Gene Variant Detail

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Gene KIT
Variant D816G
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions KIT D816G lies within the protein kinase domain of the Kit protein (UniProt.org). D816G results in constitutive phosphorylation of Kit, is transforming in culture, and confers resistance to crizotinib (PMID: 27068398).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT act mut KIT D816G

KIT mutant KIT exon17 KIT D816X KIT D816G

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Transcript NM_000222.3
gDNA chr4:g.54733155A>G
cDNA c.2447A>G
Protein p.D816G
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.