ROS1 G2032K
Gene Variant Detail

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Gene ROS1
Variant G2032K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 G2032K lies within the protein kinase domain of the Ros1 protein (UniProt.org). G2032K has been associated with secondary drug resistance (PMID: 32208297), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 G2032K

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Transcript NM_002944.3
gDNA chr6:g.117317183_117317184delGGinsAA
cDNA c.6094_6095delGGinsAA
Protein p.G2032K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944 chr6:g.117317183_117317184delCCinsTT c.6094_6095delGGinsAA p.G2032K RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117317183_117317184delGGinsAA c.6094_6095delGGinsAA p.G2032K RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117317186_117317187delGGinsAA c.6094_6095delGGinsAA p.G2032K RefSeq GRCh38/hg38
XM_011536051 chr6:g.117317186_117317187delCCinsTT c.6094_6095delGGinsAA p.G2032K RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117317183_117317184delGGinsAA c.6094_6095delGGinsAA p.G2032K RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117317186_117317187delGGinsAA c.6094_6095delGGinsAA p.G2032K RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References