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Gene KIT
Variant W582*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions KIT W582* results in a premature truncation of the Kit protein at amino acid 582 of 976 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), W582* is predicted to lead to a loss of Kit protein function.
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon11 KIT W582*

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Transcript NM_000222.3
gDNA chr4:g.54727513G>A
cDNA c.1745G>A
Protein p.W582*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222 chr4:g.54727513G>A c.1745G>A p.W582* RefSeq GRCh38/hg38
XM_017008178 chr4:g.54727513G>A c.1745G>A p.W582* RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54727513G>A c.1745G>A p.W582* RefSeq GRCh38/hg38
XM_017008178.1 chr4:g.54727513G>A c.1745G>A p.W582* RefSeq GRCh38/hg38
NM_001385285.1 chr4:g.54727513G>A c.1745G>A p.W582* RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54727513G>A c.1745G>A p.W582* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References