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Gene TP53
Variant R174Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 R174Q lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). R174Q has been identified in sequencing studies (PMID: 31328403), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 R174Q

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Transcript NM_000546.6
gDNA chr17:g.7675091_7675092delAGinsCA
cDNA c.520_521delAGinsCA
Protein p.R174Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001276760.3 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675091_7675092delCTinsTG c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126116.2 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276697.3 chr17:g.7670710_7670711delGTinsAA c.521_522delGTinsAA p.R174Q RefSeq GRCh38/hg38
NM_001276696 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126118.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001276696.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126118 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675091_7675092delCTinsTG c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126116.1 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126117.1 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126117.2 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276761 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276695.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_000546 chr17:g.7675091_7675092delCTinsTG c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276697.1 chr17:g.7670710_7670711delGTinsAA c.521_522delGTinsAA p.R174Q RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126116 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276761.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001276697 chr17:g.7670710_7670711delACinsTT c.521_522delGTinsAA p.R174Q RefSeq GRCh38/hg38
NM_001126115 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276695 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675091_7675092delCTinsTG c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001276760.1 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001126117 chr17:g.7673703C>T c.521G>A p.R174Q RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675091_7675092delAGinsCA c.520_521delAGinsCA p.R174Q RefSeq GRCh38/hg38
NM_001276760 chr17:g.7674893C>T c.521G>A p.R174Q RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References