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Gene ATR
Variant Q1845*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ATR Q1845* results in a premature truncation of the Atr protein at amino acid 1845 of 2644 (UniProt.org). Due to the loss of the PI3K/PI4K domain and the FATC domain (UniProt.org), Q1845* is predicted to lead to a loss of Atr protein function.
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR Q1845*

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Transcript NM_001184.4
gDNA chr3:g.142498622G>A
cDNA c.5533C>T
Protein p.Q1845*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184.3 chr3:g.142498622G>A c.5533C>T p.Q1845* RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142498622G>A c.5533C>T p.Q1845* RefSeq GRCh38/hg38
NM_001184 chr3:g.142498622G>A c.5533C>T p.Q1845* RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142498622G>A c.5533C>T p.Q1845* RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References