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Gene KIT
Variant T670E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KIT T670E lies within the protein kinase domain of the Kit protein (UniProt.org). T670E has been identified in sequencing studies (PMID: 25886408, PMID: 19834613, PMID: 35194937), but has not been biochemically characterized and therefore, its effect on Kit protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon14 KIT T670E

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Transcript NM_000222.3
gDNA chr4:g.54729352_54729353delACinsGA
cDNA c.2008_2009delACinsGA
Protein p.T670E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017008178 chr4:g.54729352_54729353delACinsGA c.2008_2009delACinsGA p.T670E RefSeq GRCh38/hg38
XM_017008178.1 chr4:g.54729352_54729353delACinsGA c.2008_2009delACinsGA p.T670E RefSeq GRCh38/hg38
NM_000222 chr4:g.54729352_54729353delACinsGA c.2008_2009delACinsGA p.T670E RefSeq GRCh38/hg38
NM_001385285.1 chr4:g.54729352_54729353delACinsGA c.2008_2009delACinsGA p.T670E RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54729352_54729353delACinsGA c.2008_2009delACinsGA p.T670E RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54729352_54729353delACinsGA c.2008_2009delACinsGA p.T670E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT T670E Advanced Solid Tumor resistant Imatinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing KIT T670E demonstrated resistance to Gleevec (imatinib) in culture (PMID: 35194937). 35194937
KIT T670E Advanced Solid Tumor sensitive Nintedanib Preclinical - Cell culture Actionable In a preclinical study, Ofev (nintedanib) inhibited proliferation of transformed cells expressing KIT T670E in culture (PMID: 35194937). 35194937
KIT T670E Advanced Solid Tumor sensitive Sunitinib Preclinical - Cell culture Actionable In a preclinical study, Sutent (sunitinib) inhibited proliferation of transformed cells expressing KIT T670E in culture (PMID: 35194937). 35194937
KIT T670E Advanced Solid Tumor resistant Avapritinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing KIT T670E demonstrated resistance to Ayvakit (avapritinib) in culture (PMID: 35194937). 35194937
KIT T670E Advanced Solid Tumor resistant Ripretinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing KIT T670E demonstrated resistance to Qinlock (ripretinib) in culture (PMID: 35194937). 35194937