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Gene PTEN
Variant I8N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN I8N lies within the lipid binding domain of the Pten protein (PMID: 25263454). I8N has not been characterized in the scientific literature and therefore, its effect on Pten protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN I8N

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Transcript NM_000314.8
gDNA chr10:g.87864492T>A
cDNA c.23T>A
Protein p.I8N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87864492T>A c.23T>A p.I8N RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87864492T>A c.23T>A p.I8N RefSeq GRCh38/hg38
NM_000314 chr10:g.87864492T>A c.23T>A p.I8N RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References