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Gene ARID1A
Variant P1898Hfs*25
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ARID1A P1898Hfs*25 indicates a shift in the reading frame starting at amino acid 1898 and terminating 25 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P1898Hfs*25 has not been characterized, however, due to the effects of other truncation mutations downstream of P1898 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
Associated Drug Resistance
Category Variants Paths

ARID1A mutant ARID1A inact mut ARID1A P1898Hfs*25

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Transcript NM_006015.6
gDNA chr1:g.26779591delC
cDNA c.5693delC
Protein p.P1898Hfs*25
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006015 chr1:g.26779591delC c.5693delC p.P1898Hfs*25 RefSeq GRCh38/hg38
NM_006015.5 chr1:g.26779591delC c.5693delC p.P1898Hfs*25 RefSeq GRCh38/hg38
NM_006015.6 chr1:g.26779591delC c.5693delC p.P1898Hfs*25 RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References