PIK3CA E453_L455delinsV
Gene Variant Detail

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Gene PIK3CA
Variant E453_L455delinsV
Impact List indel
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453_L455delinsV results in the deletion of three amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 453 to 455, combined with the insertion of a valine (V) at the same site (UniProt.org). E453_L455delinsV has not been characterized in the scientific literature and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453_L455delinsV

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Transcript NM_006218.4
gDNA chr3:g.179210292_179210297delAAGATT
cDNA c.1358_1363delAAGATT
Protein p.E453_L455delinsV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
NM_006218 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210292_179210297delAAGATT c.1358_1363delAAGATT p.E453_L455delinsV RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References