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Gene NRAS
Variant A146T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions NRAS A146T does not lie within any known functional domains of the Nras protein (UniProt.org). A146T results in increased Nras activity likely due to increased GDP/GTP exchange rate, activation of downstream signaling, and is identified as a secondary mutation conferring resistance to Braf and Mek inhibitors in culture (PMID: 22389471, PMID: 3043178).
Associated Drug Resistance Y
Category Variants Paths

NRAS mutant NRAS act mut NRAS A146T

NRAS mutant NRAS exon4 NRAS A146X NRAS A146T

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Transcript NM_002524.5
gDNA chr1:g.114709583C>T
cDNA c.436G>A
Protein p.A146T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114709583C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114709583C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114709583C>T c.436G>A p.A146T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries