NRAS A146T
Gene Variant Detail

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Gene NRAS
Variant A146T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions NRAS A146T does not lie within any known functional domains of the Nras protein (UniProt.org). A146T has not been characterized, but can be predicted to lead to a gain of Nras protein function and activation of downstream signaling based on the effects of HRAS A146T (PMID: 24224811, PMID: 21850009).
Associated Drug Resistance Y
Category Variants Paths

NRAS mutant NRAS act mut NRAS A146T

NRAS mutant NRAS exon4 NRAS A146X NRAS A146T

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Transcript NM_002524.5
gDNA chr1:g.114709583C>T
cDNA c.436G>A
Protein p.A146T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114709583C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114709583C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114709583C>T c.436G>A p.A146T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries