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Gene NRAS
Variant A18T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions NRAS A18T lies within a GTP-binding region of the Nras protein (UniProt.org). A18T results in MAPK/ERK pathway activation similar to wild-type Nras in an in vitro assay (PMID: 34117033), and therefore, is predicted to have no effect on Nras protein function.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon2 NRAS A18T

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Transcript NM_002524.5
gDNA chr1:g.114716109C>T
cDNA c.52G>A
Protein p.A18T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114716109C>T c.52G>A p.A18T RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716109C>T c.52G>A p.A18T RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716109C>T c.52G>A p.A18T RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References