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Gene | NRAS |
Variant | A18T |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | NRAS A18T lies within a GTP-binding region of the Nras protein (UniProt.org). A18T results in MAPK/ERK pathway activation similar to wild-type Nras in an in vitro assay (PMID: 34117033), and therefore, is predicted to have no effect on Nras protein function. |
Associated Drug Resistance | |
Category Variants Paths |
NRAS mutant NRAS exon2 NRAS A18T |
Transcript | NM_002524.5 |
gDNA | chr1:g.114716109C>T |
cDNA | c.52G>A |
Protein | p.A18T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002524 | chr1:g.114716109C>T | c.52G>A | p.A18T | RefSeq | GRCh38/hg38 |
NM_002524.4 | chr1:g.114716109C>T | c.52G>A | p.A18T | RefSeq | GRCh38/hg38 |
NM_002524.5 | chr1:g.114716109C>T | c.52G>A | p.A18T | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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