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NRAS S65C - Gene Variant Detail

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Gene NRAS
Variant S65C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS S65C does not lie within any known functional domains of the Nras protein (UniProt.org). S65C results in increased phosphorylation of Mek and Erk in cell culture (PMID: 24798740), and is predicted to confer a loss of function to the Nras protein based on the effects of other activating Ras mutations (PMID: 22589270).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS S65C

NRAS mutant NRAS exon3 NRAS S65C

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Transcript NM_002524.5
gDNA chr1:g.114713897T>A
cDNA c.193A>T
Protein p.S65C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114713897T>A c.193A>T p.S65C RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713897T>A c.193A>T p.S65C RefSeq GRCh38/hg38
NM_002524 chr1:g.114713897T>A c.193A>T p.S65C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References