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NRAS G12A - Gene Variant Detail

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Gene NRAS
Variant G12A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12A is hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12A has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G12A and KRAS G12A, which results in decreased GTPase activity, loss of response to GTPase-activating proteins, and transformation of cultured cells (PMID: 6092966, PMID: 26037647).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12A

NRAS mutant NRAS exon2 NRAS G12X NRAS G12A

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Transcript NM_002524.5
gDNA chr1:g.114716126C>G
cDNA c.35G>C
Protein p.G12A
Source Database RefSeq
Genome Build GRCh38/hg38

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