NRAS G12A
Gene Variant Detail

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Gene NRAS
Variant G12A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12A is hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12A results in increased Erk1/2 and Stat5 phosphorylation and transformation in culture (PMID: 35211470), and can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G12A and KRAS G12A, which results in decreased GTPase activity, loss of response to GTPase-activating proteins, and transformation of cultured cells (PMID: 6092966, PMID: 26037647).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12A

NRAS mutant NRAS exon2 NRAS G12X NRAS G12A

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Transcript NM_002524.5
gDNA chr1:g.114716126C>G
cDNA c.35G>C
Protein p.G12A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716126C>G c.35G>C p.G12A RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716126C>G c.35G>C p.G12A RefSeq GRCh38/hg38
NM_002524 chr1:g.114716126C>G c.35G>C p.G12A RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G12A melanoma predicted - sensitive Belvarafenib Case Reports/Case Series Actionable In a clinical case study, Belvarafenib (HM95573) treatment resulted in a partial response with a progression-free survival of 4.2 months in a melanoma patient harboring NRAS G12A (PMID: 38470950). 38470950