NRAS G12N - Gene Variant Detail

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Gene NRAS
Variant G12N
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12N is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12N has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G12N, which results in transformation in cell culture (PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12N

NRAS mutant NRAS exon2 NRAS G12X NRAS G12N

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Transcript NM_002524.5
gDNA chr1:g.114716126_114716127delGGinsAA
cDNA c.34_35delGGinsAA
Protein p.G12N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716126_114716127delGGinsAA c.34_35delGGinsAA p.G12N RefSeq GRCh38/hg38
NM_002524 chr1:g.114716126_114716127delCCinsTT c.34_35delGGinsAA p.G12N RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716126_114716127delGGinsAA c.34_35delGGinsAA p.G12N RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References