NRAS G12N
Gene Variant Detail

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Gene NRAS
Variant G12N
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12N is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12N results in Erk and Stat5 phosphorylation to similar levels of wild-type Nras, and transforming activity comparable to NRAS G12D in culture (PMID: 35211470), increased SRE-mediated transcriptional activation, perinuclear localization, and increased histone acetylation (PMID: 29511684), and can be predicted to lead to a loss of Nras protein function and activation of downstream signaling based on the effects of other NRAS G12 mutations.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12N

NRAS mutant NRAS exon2 NRAS G12X NRAS G12N

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Transcript NM_002524.5
gDNA chr1:g.114716126_114716127delGGinsAA
cDNA c.34_35delGGinsAA
Protein p.G12N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716126_114716127delGGinsAA c.34_35delGGinsAA p.G12N RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716126_114716127delGGinsAA c.34_35delGGinsAA p.G12N RefSeq GRCh38/hg38
NM_002524 chr1:g.114716126_114716127delCCinsTT c.34_35delGGinsAA p.G12N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References