NRAS G12R
Gene Variant Detail

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Gene NRAS
Variant G12R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12R is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12R results in increased MAPK/ERK pathway activation in an in vitro assay (PMID: 34117033), demonstrates Erk phosphorylation similar to wild-type Nras but increased Stat5 phosphorylation in culture (PMID: 35211470), and is transforming (PMID: 34117033, PMID: 35211470), and is predicted to lead to a loss of Nras protein function and activation of downstream signaling based on the effects of HRAS G12R (PMID: 3042780, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12R

NRAS mutant NRAS exon2 NRAS G12X NRAS G12R

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Transcript NM_002524.5
gDNA chr1:g.114716127C>G
cDNA c.34G>C
Protein p.G12R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716127C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_002524 chr1:g.114716127C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716127C>G c.34G>C p.G12R RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Active, not recruiting USA 0
NCT05726864 Phase Ib/II ELI-002 A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors (AMPLIFY-7P) Active, not recruiting USA 0
NCT04853017 Phase Ib/II ELI-002 A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors (AMPLIFY-201) Completed USA 0