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Gene NRAS
Variant G13D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G13D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13D confers a loss of function on Nras protein as indicated by increased GTP-bound Nras, which leads to activation of downstream pathway signaling in cell culture (PMID: 17517660).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13D

NRAS mutant NRAS exon2 NRAS G13X NRAS G13D

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Transcript NM_002524.5
gDNA chr1:g.114716123C>T
cDNA c.38G>A
Protein p.G13D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716123C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_002524 chr1:g.114716123C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716123C>T c.38G>A p.G13D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05726864 Phase Ib/II ELI-002 A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors (AMPLIFY-7P) Recruiting USA 0
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Active, not recruiting USA 0